1,3-Dimethyl-5-methylsulfonyl-1H-pyrazolo[4,3-e][1,2,4]triazine
نویسندگان
چکیده
In the title compound, C(7)H(9)N(5)O(2)S, the pyrazolo-[4,3-e][1,2,4]triazine fused-ring system is essentially planar [maximum deviation = 0.0420 (3) Å]. In the crystal, mol-ecules related by twofold axes are linked into a mol-ecular net via inter-molecular C-H⋯O and C-H⋯N hydrogen bonds. π-π inter-actions are observed between the triazine and pyrazole rings of mol-ecules related by the the twofold axis and inversion symmetry with centroid-centroid distances of 3.778 (3) and 3.416 (3) Å, respectively.
منابع مشابه
Ring Transformation of Oxazolo [3,2-b][1,2,4] Triazines
6-Methyl-2-phenyl-7H-Oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). Treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4H-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1H)-one (3).
متن کاملNon-classical transformation of benzendiazonium hydrogen sulfates. Access to 1,3-dimethylisochromeno[4,3-c]pyrazol-5(1H)-one, a potential benzodiazepine receptor ligand.
The compound 2-((1,3-dimethyl-1H-pyrazol-5-yl)(methyl)carbamoyl)benzene-diazonium hydrogen sulfate (10) was reacted with copper sulfate and sodium chloride, in the presence of ascorbic acid as reducing agent, to afford a mixture of the chlorinated epimers 4'-chloro-2,2',5'-trimethyl-2',4'-dihydrospiro[isoindoline-1,3'-pyrazol]-3-one (18) and (19), the epimers 4'-hydroxy-2,2',5'-trimethyl-2',4'-...
متن کاملTandem Reactions Using Nitrile Imines: Synthesis of Some Novel Heterocyclic Compounds with Expected Biological Activity
New functionalized 7,9-dimethylpyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidine5,6,8(1H,7H,9H)-trione derivatives were synthesized via reaction of the hydrazonoyl halides with 7,8-dihydro-1,3-dimethyl-7-thioxopyrimido[4,5-d]pyrimidine-2,4,5(1H,3H,6H)trione. The biological activity of the products has been evaluated. The mechanism and the regioselectivity of the studied reactions have been discus...
متن کاملSynthesis and isomerization of some novel pyrazolopyrimidine and pyrazolotriazolopyrimidine derivatives.
4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triaz...
متن کاملThe Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives
A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed in order to explore their affinity and selectivity profile at the four adenosine receptor subtypes. In particular, the PTP scaffold was conjugated at the C2 position with the 1-(3-trifluoromethyl-benzyl)-1H-pyrazole, a group believed to confer potency and selectivity toward the human (h) A2B ade...
متن کامل